Gene study explores mechanisms behind peptic ulcers

University of Liverpool researchers identified a single nucleotide polymorphism in a gene cluster that may play a role in the risk of peptic ulcers among people who use nonsteroidal anti-inflammatory treatments. Adults with peptic ulcer disease who were genotyped for the study were twice as likely to use NSAIDs as those without the condition. Statistical analysis found a link between an SNP in the cytochrome P450 2C cluster — important for metabolism of drugs and endogenous compounds — and peptic ulcer disease, independent of infection with Helicobacter pylori or NSAID use. MedWire News (U.K.) (1/31)