Researchers identify 163 genetic loci associated with IBD

A new meta-analysis published in the journal Nature by U.K. researchers reports that 163 genetic loci are linked to inflammatory bowel disease (IBD) and some also are involved with other immune system diseases. This review of genome-wide association studies in Crohn’s disease and ulcerative colitis found that the loci associated with susceptibility to IBD also overlapped with loci associated with the response to mycobacterial infection. “Most of the evidence relating to possible causal genes points to an essential role for host defense against infection in inflammatory bowel disease,” the researchers said. News (11/2)