The American Journal of Gastroenterology invites submissions for a special issue focused on Artificial Intelligence (AI) Clinical Applications in Gastroenterology and Hepatology.
AI and machine learning are rapidly transforming clinical medicine, offering novel tools for disease prediction, diagnostics, risk stratification, and personalized care. In gastroenterology and hepatology, AI has already demonstrated potential in endoscopic image analysis, histopathology, radiologic interpretation, electronic health record (EHR) mining, and clinical decision support.
We seek high-quality original research and reviews that explore the clinical use of AI applications across the full spectrum of clinical applications in gastrointestinal and liver diseases. Studies emphasizing performance comparison of AI to conventional decision making and AI cost-effectiveness analyses are encouraged. Contributions that address the ethical, regulatory, and practical challenges of AI integration into clinical workflows are also encouraged.
Topics of interest include, but are not limited to:
- AI-assisted endoscopic detection and characterization of lesions
- Predictive models for IBD, cirrhosis, liver cancer, and GI malignancies
- Machine learning in hepatology diagnostics and transplant evaluation
- Applications of natural language processing in care models
- Real-world deployment and clinical utility of AI systems
- Regulatory, ethical, and medico-legal considerations in AI for GI care
All submissions will undergo rigorous peer review. Select papers may be highlighted with editorial commentary or featured in companion digital content.
Please clearly state in your cover letter that your manuscript is intended for the AI Clinical Applications in GI and Hepatology special issue. This issue is scheduled to publish in Fall 2025. Depending on the responses to this request, some accepted manuscripts may be published in other upcoming issues of AJG.
Manuscripts should be submitted through the journal submission system.
Submission Window Closes: August 31, 2025
