All research presented at ACG 2025 is strictly embargoed until 12:00 pm local Arizona Time, which aligns with Pacific Daylight Time (PDT)/3:00 pm ET on Sunday, October 26, 2025.
Oral 2 – Higher Sessile Serrated Lesion Detection Rates Are Associated With Lower Risk for Post-Colonoscopy Colorectal Cancer: Data From the New Hampshire Colonoscopy Registry
Monday, October 27, 2025 | 8:12 AM – 8:24 AM PDT | North Ballroom 120D
Author Insight from Rachael Hagan, DO
What’s new here and important for clinicians?
Recent ACG/ASGE guidelines recommend calculating adenoma detection rate using all examinations, rather than screening exams alone. This approach narrows the confidence interval, mitigates gaming by endoscopists, and increases the sample size.
In our study, we applied this same principle to sessile serrated lesion detection rates (SSLDR) by comparing calculations using all examinations versus screening exams alone. We found that a SSLDR of 8% using all examinations provides the most protection from post-colonoscopy colorectal cancer.
To our knowledge, this is among the first studies to evaluate for SSLDR using all examinations. We hope these findings will inform future guidelines and support adopting an aspirational SSLDR target of greater than 8%, calculated from all colonoscopies.
What do patients need to know?
Colorectal cancer (CRC) can be prevented by removing precancerous growths, called polyps, during a colonoscopy. A certain type of polyp, called serrated polyps, can be difficult to detect but are important to remove as they can progress to CRC if missed.
Gastroenterologists track how often they find and remove precancerous growths using detection rates. Higher detection rates are linked to a lower risk of developing CRC. This study found that endoscopists should include all colonoscopy examinations when calculating their detection rates for serrated polyps, not just screening exams, as has been standard practice. They should aim for the highest detection rate possible, but at least 8%. These findings may make colonoscopy screening more effective in preventing CRC.
Author Contact
Rachael Hagan, DO
University of Connecticut Health
Farmington, CT
rhagen [at] uchc.edu
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