*EMBARGOED All research presented at the 2022 ACG Annual Scientific Meeting and Postgraduate Course is strictly embargoed until Sunday, October 23, 2022, at 12:00 pm EDT.

Irene Sarosiek, MD

Irene Sarosiek, MD

Oral 9 – Combining Surgical Pyloroplasty and Gastric Electrical Stimulation in Gastroparetic Patients Is Superior to Pyloroplasty Alone: A Randomized Double Blind Placebo Control Trial

Monday, October 24, 2022 | 10:06 AM – 10:18 AM ET | Location: Hall C2

Author Insight from Irene Sarosiek, MD, Texas Tech University Health Sciences Center


What’s new here and important for clinicians?

In a randomized double blind study, 30 patients with drug-refractory gastroparesis underwent Heineken-Mikulicz pyloroplasty with the implantation of a gastric electrical stimulation (GES) system. Patients were randomized into 2 groups: In 15 subjects, GES was kept OFF (GES-OFF group) and in 15 others it was turned ON after surgery (GES-ON group). After 3 months of double blind placebo control phase of the trial, GES was turned ON in GES-OFF group, while GES system continues to be on in GES-ON group. Patients were followed up for additional 3 months. This study demonstrated that GES ON plus pyloroplasty was significantly more effective in controlling gastroparesis symptoms and particularly vomiting when compared with pyloroplasty alone (GES-OFF group). In both GES-ON and GES-OFF groups, gastric emptying was accelerated suggesting a role for pyloroplasty in these patients. Hospitalization was significantly reduced in GES-ON vs. GES-OFF group. Implantation of GES system with pyloroplasty could be accomplished simultaneously with no major technical or surgical complications.

What do patients need to know?

The most important message for patients is the fact that, after failing all approved medication (this list is very short) there is a hope to control their severe symptoms of gastroparesis with utilization of the implantable system and pyloroplasty.

Read the Abstract

Author Contact
Irene Sarosiek, MD, Texas Tech University Health Sciences Center


irene.sarosiek [at] ttuhsc.edu


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