Dementia risk linked to PPIs

German researchers reporting in JAMA Neurology found an association between proton pump inhibitors and greater likelihood of developing dementia. The research, based on administrative data from patients without dementia who were 75 or older, found those who used PPIs had a 44% higher risk of dementia than patients who did not take the medications, although researchers acknowledged that sociodemographic parameters and other potentially confounding factors in this population were not included in the analysis.

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