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Gi.org / Liver

Evidence-Based GI

EBGI Category: Liver


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  • Surgery in cirrhosis: Strategies for risk stratification and optimization

    American College of Gastroenterology / EBGI Articles / Liver / Surgery in cirrhosis: Strategies for risk stratification and optimization

    Patients with cirrhosis face some of the highest surgical risks, and until now, guidance towards the approach to perioperative management has been fragmented and inconsistent. This new ACG clinical guideline consolidates the evidence into a structured roadmap comparing risk calculators, CSPH evaluation, and procedure-specific considerations.

  • Semaglutide for the treatment of metabolic dysfunction-associated steatohepatitis

    American College of Gastroenterology / EBGI Articles / Liver / Semaglutide for the treatment of metabolic dysfunction-associated steatohepatitis

    Semaglutide for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis Paul Y. Kwo, MD, FACG  Professor of Medicine and Director of  Hepatology,…

  • Fueling the Failing Liver—ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease

    American College of Gastroenterology / EBGI Articles / Liver / Fueling the Failing Liver—ACG Clinical Guideline: Malnutrition and Nutritional Recommendations in Liver Disease

    The authors highlight the 2025 ACG Guideline on malnutrition and nutritional recommendations in liver disease, emphasizing early screening, individualized nutritional goals, and targeted supplementation to improve outcomes across various etiologies and stages of chronic liver disease.

  • Increased ATTENTION to Early Initiation of Antiviral Therapies in Chronic Hepatitis B Based on Viral Load

    American College of Gastroenterology / EBGI Articles / Liver / Increased ATTENTION to Early Initiation of Antiviral Therapies in Chronic Hepatitis B Based on Viral Load

    This evidence-based summary examines a RCT which aimed to assess the efficacy of early antiviral treatment with tenofovir alafenamide in patients with non-cirrhotic chronic HBV and moderate to high viremia.

  • Challenges of Full FDA Approval for Obeticholic Acid Based on Reduction of Hepatic PBC Clinical Events

    American College of Gastroenterology / EBGI Articles / Liver / Challenges of Full FDA Approval for Obeticholic Acid Based on Reduction of Hepatic PBC Clinical Events

    This summary reviews the challenges of FDA approval for obeticholic acid in an evidence-based review of the COBALT study.

  • Safety and Tolerability of Medications for Alcohol Use Disorder

    American College of Gastroenterology / EBGI Articles / General GI / Safety and Tolerability of Medications for Alcohol Use Disorder

    Safety and Tolerability of Medications for Alcohol Use Disorder Nikki Duong, MD1 and Paul Y. Kwo, MD, FACG2 1Clinical Assistant…

  • Decreasing Cirrhosis Risk in MASLD: Don’t Drink Alcohol!

    American College of Gastroenterology / EBGI Articles / Liver / Decreasing Cirrhosis Risk in MASLD: Don’t Drink Alcohol!

    Decreasing Cirrhosis Risk in MASLD: Don’t Drink Alcohol! Nicole E. Rich, MD, MSCS Assistant Professor, Associate Director of the Liver…

  • Tirzepatide Produces NASH Resolution and Decreases Fibrosis: Results from the SYNERGY-NASH Trial

    American College of Gastroenterology / EBGI Articles / Liver / Tirzepatide Produces NASH Resolution and Decreases Fibrosis: Results from the SYNERGY-NASH Trial

    Tirzepatide Produces NASH Resolution and  Decreases Fibrosis: Results from the SYNERGY-NASH Trial Nicole E. Rich, MD MSCS Assistant Professor, Associate…

  • First FDA-Approved NASH Treatment Produces NASH Resolution and Decreases Fibrosis: Results from the MAESTRO-NASH Trial

    American College of Gastroenterology / EBGI Articles / Liver / First FDA-Approved NASH Treatment Produces NASH Resolution and Decreases Fibrosis: Results from the MAESTRO-NASH Trial

    First FDA-Approved NASH Treatment Produces NASH Resolution and Decreases Fibrosis: Results From the Landmark Phase 3 MAESTRO-NASH Trial Phillip Leff,…

  • How Effective Are Obesity Medications for Reducing Hepatic Decompensation in NASH?

    American College of Gastroenterology / EBGI Articles / Liver / How Effective Are Obesity Medications for Reducing Hepatic Decompensation in NASH?

    How Effective are Obesity Medications for Reducing Hepatic Decompensation in MASH? Philip Schoenfeld, MD, MSEd, MSc (Epi) Chief (Emeritus), Gastroenterology…

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