The term “advanced adenoma” carries an ominous connotation, as it signifies a high risk for colorectal cancer (CRC), causing concern for both patients and clinicians. Evidence, including data from the New Hampshire Colonoscopy Registry, supports this concern by showing that individuals with advanced adenomas face a higher risk of future advanced neoplasia—defined as the combined risk of CRC and other advanced adenomas—compared to those with non-advanced or no polyps.

In this single-center pilot study, FMT was safe and well tolerated, with no related serious adverse events and early signals of reduced bloodstream infections and antibiotic use among LTACH patients colonized with MDROs.

With presumed standard-of-care prophylactic colectomies and surveillance colonoscopies (in the United States), most FAP patients will fortunately not develop cancer, although the risk overall is still markedly higher than the average-risk patient without FAP.

In this multicenter RCT of 356 patients across 19 hospitals, prophylactic clipping after EMR of large (≥20 mm) proximal colon polyps did not reduce delayed bleeding (9.0% vs. 6.1%, P = 0.30).

This is the first study to assess the impact of exposure to AI CADe on colonoscopy quality and physician performance in the absence of AI assistance. One of the posited risks of AI tools has been a decline in human-only colonoscopy quality, and this study provides important, novel observational data on how these AI tools may potentially negatively impact physician performance.

This summary reviews the 2025 Lancet article on the effect of invitation to colonoscopy versus fFIT screening on colorectal cancer mortality. Is an invitation to colorectal cancer (CRC) screening using fecal immunochemical test (FIT) non-inferior to colonoscopy?

This summary reviews Anderson JC, Rex DK, Mackenzie TA, Hisey W, Robinson CM, Butterly LF. Adenoma detection rates calculated using all examinations are associated with lower risk for postcolonoscopy colorectal cancer: Data from the New Hampshire Colonoscopy Registry. Am J Gastroenterol. 2025. doi: 10.14309/ajg.0000000000003488.

This summary reviews Pohl H, Rex DK, Barber J, et al. Cold snare endoscopic resection for large colon polyps: A randomised trial. Gut Published Online First: 19 May 2025. doi: 10.1136/gutjnl-2025-335075.

Can non-invasive fecal immunochemical tests be used to extend surveillance intervals for colonoscopy among Lynch syndrome patients?

Tulisokibart: A New Drug for Moderate-to-Severe UC That May Come With Personalized Medicine Ellen Axenfeld, MD1 and Elie S. Al…