Evidence-Based GI
EUS-Guided Versus Surgical Gastroenterostomy: Which Endures? (The ENDURO trial) Margaret J. Zhou, MD Clinical Assistant Professor of Medicine, Gastroenterology &…
In this single-center pilot study, FMT was safe and well tolerated, with no related serious adverse events and early signals of reduced bloodstream infections and antibiotic use among LTACH patients colonized with MDROs.
This updated 2025 guideline addresses critical topics including prevention of mother-to-child transmission and horizontal transmission, treatment in immune-tolerant and indeterminate phases (“grey zone”), treatment discontinuation, and hepatocellular carcinoma (HCC) surveillance.
The guidelines still emphasize the importance of preconception counseling and achieving disease remission prior to conception to lower the risk of adverse pregnancy outcomes. Decreased fertility remains an important outcome in post-surgical patients, especially in patients with ileal pouch anal anastomosis.
Many gastroenterologists encounter patients with subtle tongues of salmon-colored mucosa or an irregular Z-line that is biopsied, but guidelines disagree on whether segments <1 cm should be labeled as BE or followed at all. Some societies exclude USBE due to measurement variability and presumed minimal cancer risk. This study provides long-term outcome data to help clinicians understand whether USBE is clinically meaningful, challenging the assumption that these short segments are benign and transient.
With presumed standard-of-care prophylactic colectomies and surveillance colonoscopies (in the United States), most FAP patients will fortunately not develop cancer, although the risk overall is still markedly higher than the average-risk patient without FAP.
In this multicenter RCT of 356 patients across 19 hospitals, prophylactic clipping after EMR of large (≥20 mm) proximal colon polyps did not reduce delayed bleeding (9.0% vs. 6.1%, P = 0.30).
This study offers contemporary evidence on GLP-1RA association with overall cancer risk in adults with obesity, particularly for hormonally driven malignancies, while raising questions about kidney cancer that warrant ongoing vigilance.
The addition of bedtime lafutidine 10 mg to esomeprazole 20 mg twice daily significantly increased nocturnal intragastric pH >4 holding time ratios and decreased the occurrence of nocturnal acid breakthrough. GERD patients who added lafutidine experienced a more pronounced improvement in sleep quality, correlated with a reduction in nocturnal acid breakthrough. This bolsters existing ACG clinical guidelines for newer-generation H2RAs.
In this study, patients with proximal predominant eosinophilia were less likely to have a histologic response to proton pump inhibitors compared with those with distal predominant eosinophilia, and may provide prognostic information regarding treatment response.