Evidence-Based GI
In this multicenter RCT of 356 patients across 19 hospitals, prophylactic clipping after EMR of large (≥20 mm) proximal colon polyps did not reduce delayed bleeding (9.0% vs. 6.1%, P = 0.30).
This study offers contemporary evidence on GLP-1RA association with overall cancer risk in adults with obesity, particularly for hormonally driven malignancies, while raising questions about kidney cancer that warrant ongoing vigilance.
The addition of bedtime lafutidine 10 mg to esomeprazole 20 mg twice daily significantly increased nocturnal intragastric pH >4 holding time ratios and decreased the occurrence of nocturnal acid breakthrough. GERD patients who added lafutidine experienced a more pronounced improvement in sleep quality, correlated with a reduction in nocturnal acid breakthrough. This bolsters existing ACG clinical guidelines for newer-generation H2RAs.
In this study, patients with proximal predominant eosinophilia were less likely to have a histologic response to proton pump inhibitors compared with those with distal predominant eosinophilia, and may provide prognostic information regarding treatment response.
Patients with cirrhosis face some of the highest surgical risks, and until now, guidance towards the approach to perioperative management has been fragmented and inconsistent. This new ACG clinical guideline consolidates the evidence into a structured roadmap comparing risk calculators, CSPH evaluation, and procedure-specific considerations.
Since the 2018 guideline, multiple new biologic and small molecule agents have been approved for Crohn’s disease, and data have emerged supporting earlier initiation of advanced therapies to improve long-term outcomes. The 2025 update reflects this shift toward early treat-to-target strategies, the de-implementation of ineffective agents, and individualized therapy selection based on disease phenotype, prior exposures, and patient preferences.
This is the first study to assess the impact of exposure to AI CADe on colonoscopy quality and physician performance in the absence of AI assistance. One of the posited risks of AI tools has been a decline in human-only colonoscopy quality, and this study provides important, novel observational data on how these AI tools may potentially negatively impact physician performance.
Semaglutide for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis Paul Y. Kwo, MD, FACG Professor of Medicine and Director of Hepatology,…
This summary reviews the 2025 Lancet article on the effect of invitation to colonoscopy versus fFIT screening on colorectal cancer mortality. Is an invitation to colorectal cancer (CRC) screening using fecal immunochemical test (FIT) non-inferior to colonoscopy?
Evidence-based summary of the 2025 ACG updated guidelines for ulcerative colitis. How can healthcare providers manage ulcerative colitis (UC) in adults? What are appropriate therapies for mild-to-moderate disease, moderate-to severe disease and the hospitalized patient?