Since the 2018 guideline, multiple new biologic and small molecule agents have been approved for Crohn’s disease, and data have emerged supporting earlier initiation of advanced therapies to improve long-term outcomes. The 2025 update reflects this shift toward early treat-to-target strategies, the de-implementation of ineffective agents, and individualized therapy selection based on disease phenotype, prior exposures, and patient preferences.
This is the first study to assess the impact of exposure to AI CADe on colonoscopy quality and physician performance in the absence of AI assistance. One of the posited risks of AI tools has been a decline in human-only colonoscopy quality, and this study provides important, novel observational data on how these AI tools may potentially negatively impact physician performance.
Semaglutide for the Treatment of Metabolic Dysfunction-Associated Steatohepatitis Paul Y. Kwo, MD, FACG Professor of Medicine and Director of Hepatology,…
This summary reviews the 2025 Lancet article on the effect of invitation to colonoscopy versus fFIT screening on colorectal cancer mortality. Is an invitation to colorectal cancer (CRC) screening using fecal immunochemical test (FIT) non-inferior to colonoscopy?
Evidence-based summary of the 2025 ACG updated guidelines for ulcerative colitis. How can healthcare providers manage ulcerative colitis (UC) in adults? What are appropriate therapies for mild-to-moderate disease, moderate-to severe disease and the hospitalized patient?
This summary reviews Anderson JC, Rex DK, Mackenzie TA, Hisey W, Robinson CM, Butterly LF. Adenoma detection rates calculated using all examinations are associated with lower risk for postcolonoscopy colorectal cancer: Data from the New Hampshire Colonoscopy Registry. Am J Gastroenterol. 2025. doi: 10.14309/ajg.0000000000003488.
This summary reviews Pohl H, Rex DK, Barber J, et al. Cold snare endoscopic resection for large colon polyps: A randomised trial. Gut Published Online First: 19 May 2025. doi: 10.1136/gutjnl-2025-335075.
Bridging the Gap: Impact of Gender-Affirming Care on IBD Flare Rates Hayley Rogers, MD1 and Nikki Duong, MD2 1Advanced Endoscopy…
ELP is a rare and under-recognized condition that presents significant diagnostic and therapeutic challenges, especially for gastroenterologists who often encounter these patients first. There is no consensus on diagnostic criteria or standard treatment, and existing histologic scoring systems are often impractical for routine use due to variability and nonspecific findings. This study introduces a visually based severity score (ELPSS) tailored for endoscopic use—similar to scoring tools in eosinophilic esophagitis—and highlights the potential of low-dose oral tacrolimus as a safe and effective treatment option for patients with moderate to severe ELP. Addressing this unmet need may improve disease recognition and long-term management.
Surveillance Endoscopy in Barrett’s Esophagus: Does It Work? Margaret J. Zhou, MD, MS Clinical Assistant Professor of Medicine, Division of…
